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New York, NY (May 12, 2017)–New lung “organoids”–tiny 3-D structures that mimic features of a full-sized lung–have been created from human pluripotent stem cells by researchers at Columbia University Medical Center (CUMC). The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.
A paper detailing the discovery was published in the April 24 online issue of Nature Cell Biology.
Organoids are 3-D structures containing multiple cell types that look and function like a full-sized organ. By reproducing an organ in a dish, researchers hope to develop better models of human diseases, and find new ways of testing drugs and regenerating damaged tissue.